The United States has long been recognized as the innovation capital of the world for life sciences, well supported through a favorable IP framework and garnering attention from overseas as a high-value market. Under increasing scrutiny and pressure on drug pricing, companies are adapting drug development and market entry strategies – keeping the patient at the center of the process, trends towards precision medicine, more targeted treatments and better-defined patient populations are benefitting drug development timelines and costs through higher trial success rates. As companies’ strategies shift, the U.S. healthcare system itself will have to be adapted to absorb curative therapies entering the market.